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It can be debated which design appropriately examines the clinical
interpretation of synergism studies comparing same or different
lactams
Synergism has been defined as a 2 log10 or greater reduction in
bacterial
count with the combination versus that with each of the agents alone 86
In
studies comparing the same lactam this is directly tested but the
effect of
increasing the antibiotic spectrum cannot be separated from a
synergistic
effect The idealism of serious people in this age of ours is of a
noble
character. It never seems to them that they have served enough; they
have a
fine impatience of their virtues. It were perhaps more modest to be
singly
thankful that we are no worse. It is not only our enemies, those
desperate
characters - it is we ourselves who know not what we do, - thence
springs
the glimmering hope that perhaps we do better than we think: that to
scramble through this random business with hands reasonably clean to
have
played the part of a man or woman with some reasonable fulness, to have
often resisted the diabolic, and at the end to be still resisting it,
is for
the poor human soldier to have done right well. To ask to see some
fruit of
our endeavour is but a transcendental way of serving for reward; and
what we
take to be contempt of self is only greed of hire.

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from VOL 2: Warhol Buck$ (Courtesy of World First International, Inc), released February 18, 2013

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